Collaboration | Organization - Faculty/Dept. | Support |
PROJECT 1 | ||
Measurement: Develop a preference-based index for Parkinson's disease. Key indicators of function
from the BHOP Parkinson's cohort will be selected by applying the Rasch
Measurement Framework along with knowledge experts input. The BHOP is providing open science data to develop a preliminary assessment tool. The BHOP team, is providing the psychometric knowledge and analysis for this project. |
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Ayse Kuspinar,
PhD Nancy Mayo, PhD Stanley Hum, PhD |
McMaster University,
School of Rehabilitation Science MUHC-RI, Center for Outcome Research and Evaluation McGill University |
Outcome development |
PROJECT 2 | ||
Project title: Protecting Vulnerable People from
Worsening Distress and Loneliness during the COVID-19 Social Isolation
Period: The Experience of People Aging with HIV This substudy of the "Action for Brain Health Now" was conducting using the BHOP to distribute a specific COVID-19 questionnaire remotely to participants to obtain longitudinal information about their mental health. Scores above a specific mental health threshold were automatically flagged for telephone or video teleconference follow-up with the study coordinator and psychological support team as needed. BHOP was selected to conduct this study because it allowed for contactless online electronic consent, email distribution of consent and survey, automatic alert based on participant response, and was expedited on the platform within a day once ethics approval was obtained. |
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Brain Health Now: Marie-Josée Brouillette, MD Lisa Koski, PhD Lesley Fellows, MD, PhD Nancy Mayo, PhD |
McGill University, Department of Psychology; MUHC-RI McGill University, Department of Psychology Montreal Neurological Insitute, Chronic Viral Illness Service MUHC-RI, Center for Outcome Research and Evaluation |
Study support |
PROJECT 3 | ||
Article title: Properties of common
anxiety scales among patient with bipolar disorder Journal of Affective Disorders, 2020, Volume 281, Pages 972-979 https://doi.org/10.1016/j.jad.2020.09.139 Abstract: Objectives: Almost half of the patients with a bipolar disorder (BD) have anxiety disorder(s) (AD) during their lifetime, but feasible measures for all AD are few. Furthermore, cognitive impairments can compromise reli- ability of existing scales, since many are needed for full coverage. Thus, we investigated how reliably patients responded to anxiety scales and any symptom overlap to propose future improvements to anxiety assessments. Methods: We collected 152 observations in patients with BD with the Clinically Useful Anxiety Outcome Scale, Social Phobia Inventory, Panic Disorder Severity Measurement, and Trauma Screening Questionnaire (in total, 57 items). The scales were analyzed as a set in a Rasch model. Results: During our analyses, we found indication that BD outpatients had dificulty differentiating response options to 70% (40/57) of items which were rescored or deleted. Only one case was misfitting (-2.65±.41). In total, 22 items were locally dependent and one indicated misfit. The final model included 25-items and fit the Rasch model (χ2=35.92, DF=50, p=.93). The model was unidimensional, without losing appropriate associations with depression (r = 0.62), suicidality (r = 0.37), and hypomania (r= -0.01). Limitations: Bolstering the size of less frequent subgroups should be accomplished in future work. Conclusion: A unidimensional rather than categorical approach to severity of anxiety might be both useful and feasible in this population. Further development of screens is necessary to enable systematic screening and measurement of anxiety in BD. |
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Quinta Seon Stanley Hum, MSc, PhD Maria Tuineag, MSc, MD Barbara Pavlova Serge Beaulieu Outi Linnaranta |
McGill University Montreal Neurological Institute McGill University, Department of psychiatry; Douglas Hospital Dalhousie University; Nova Scotia Healthy Authority McGill University, Department of psychiatry; Douglas Hospital McGill University, Department of psychiatry; Douglas Hospital |
Rasch analysis consultation and contribution to article |
PROJECT 4 | ||
Project title:
Health-Related Quality of Life in Older
Adults: Measuring What Matters to Older People Aging is not a problem to be solved rather a mystery to be lived. The strong modern bias toward medicalizing the problem of aging needs forcefully to be fought. With an increasing emphasis on prevention and health promotion, a new measure of health related quality of life (HRQL) is required. The new measure will be developed specifically for and by people living independently in the community covering domains related to active aging and active living. We will refer to this new measure as HRQL-OPAL, where OPAL is an acronym for "Older Persons for Active Living". BHOP will be used to support the roll-out of the study. The Brain Health Outcomes Unit is providing expert knowledge in remote participant recruitment and enrollment. |
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Nancy
Mayo, PhD Kim Sawchuck, PhD Ayse Kuspinar, PhD Mohammad Auais, PhD Ruth Barclay, PhD Joan J. Branin, PhD Helen Dawes, PhD Ida Korfage, PhD Carole White, PhD, RN |
McGill
University; MUHC-RI, Montreal, Canada Concordia University, Montreal, Canada McMaster University, Hamilton, Canada Queen's University, Kingston, Canada University of Manitoba, Winnipeg, Canada Center for Health and Aging, California, USA Oxford Brookes University, Oxford, UK Erasmus University, Rotterdam, Netherlands UT Health, San Antonio, USA |
Study support |
PROJECT 5 | ||
Project title: Real-time Auditory Feedback
for Improving Gait and Walking in People with Parkinson's Disease This pilot study will test whether a wearable device (The Heel2Toe sensor) can improve gait in people with Parkinsons. Objectives: The global aim of this study is (i) to contribute evidence for efficacy potential of the Heel2Toe sensor and feedback delivery mechanism in improving gait and walking, in comparison to outcomes achieved without feedback; (ii) to identify brain mechanisms underlying response to feedback; and (iii) to develop data-driven algorithms to identify gait phenotypes. BHOP will be used to support the roll-out of the study. The Brain Health Outcomes Unit will provide expert knowledge in outcome development if required. | ||
Nancy
Mayo, PhD Anne-Louise Lafontaine, MD, MSc, FRCPC Lesley Fellows, MD CM, DPhil Madeleine Sharp, MD José A. Morias, MD Nandini Dendukuri, PhD |
McGill
University, MUHC-RI McGill University Health Centre McGill University, Montreal Neurological Institute & Hospital Montreal Neurological Institute & Hospital McGill University Health Centre McGill University, Division of Experimental Medicine |
Study support |
PROJECT 6 | ||
Collaboration: Psychiatric BioBank BHOP is collaborating with the team developing the Psychiatry BioBank. BHOP will provide expert knowledge and infrastructure support to collect health assessment outcomes for the cohort. Health outcome dataset will be shared between BHOP and Psychiatry BioBank. The Psychiatry BioBank will independently manage their tissue, imaging, and health outcome dataset. |
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Psychiatry BioBank Simon Duchamre, MD, MSc, FRCPC Anne Almey, PhD BHOP Nancy Mayo, PhD Lesley Fellows, MD CM, DPhil Stanley Hum, PhD |
McGill University, The Douglas Research Centre, MUHC McGill University Health Centre McGill University, MUHC-RI McGill University, Montreal Neurological Institute & Hospital McGill University |
Study support Sharing health outcome dataset |